https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.9b10094<\/a><\/p>\n\n\n\nCitation: Eills, J.; Cavallari, E.; Carla, C.; Budker, D.; Aime, S.; Reineri, F.; J. Am. Chem. Soc. 2019, 141, 51, 20209-20214
A short Q&A with the author James Eills:<\/p>\n\n\n\n
Q: How was the idea for the project conceived? <\/p>\n\n\n\n
A: This project has been a long-term dream of mine since working with the biomolecule fumarate during my PhD. Back then I was using an alternative method to produce hyperpolarized fumarate for an entirely different purpose, and in separate projects I was working with parahydrogen-induced hyperpolarization. To have combined those two avenues of research is a gratifying conclusion to a few years of work.<\/p>\n\n\n\n
Q: Where were the experiments performed, and how long did they take?\u00a0 <\/p>\n\n\n\n
A: This work was performed in Torino in the lab of Dr Francesca Reineri and Prof. Silvio Aime. The experiments took about 5 days, which was a feat only possible thanks to the eye-watering work rate of my collaborators Dr Eleonora Cavallari and Dr Carla Carrera!<\/p>\n\n\n\n
Q: Personally, what was the most difficult part of the project?\u00a0 <\/p>\n\n\n\n
A: Leaving Torino and returning to Germany.<\/p>\n\n\n\n
Q: What comes next? <\/p>\n\n\n\n
A: These exciting results have ignited interest in our field, and in the next days I will be heading to UC Berkeley to work on applying this technique in animal imaging studies. I will be working with my collaborator Dr Danila Barskiy in the lab of Prof. Alex Pines, along with 5 other postdocs from Europe who will join for this ambitious and compelling endeavour!<\/p>\n\n\n\n Parahydrogen gas is reacted with a precursor molecule to produce fumarate, and the polarization is transferred to the 13C spin. We observe metabolism of the fumarate in cell suspensions via 13C NMR. \u00a0 <\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"We demonstrate a cheap and scalable way to form the biomolecule fumarate (a type of chemical compound) from an enriched form of hydrogen gas, which opens a door to studying metabolism and cell death in vivo via magnetic resonance imaging. The research has been featured in a JACS Spotlight: Hyperpolarized Hydrogen Empowers a New Biomarker Article URL: https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.9b10094 […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-996","post","type-post","status-publish","format-standard","hentry","category-default"],"_links":{"self":[{"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=\/wp\/v2\/posts\/996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=996"}],"version-history":[{"count":1,"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=\/wp\/v2\/posts\/996\/revisions"}],"predecessor-version":[{"id":998,"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=\/wp\/v2\/posts\/996\/revisions\/998"}],"wp:attachment":[{"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/budker.uni-mainz.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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